Exposure of persistent organic pollutants ( POPs ) in relation to high fish consumption , part 3

Individual levels of 33 PCBs (#28, #52, #47/48, #74, #66, #101, #99/113, #110, #118, #114/122, #105, #153, #138, #128/167, #156, #157, # 178, #182/187, #183, #174, #177, #172/192, #180/193, #170/190, #189, #202, # 194, #199, #196/203, #195, # 208, #207, #206), HCB, oxychlordane, p,p’-DDE and PBDE #47 were determined in 141 plasma samples (0.5-3 ml) from Swedish females with documented high consumption of fish. The analytical method used includes solid-phase extraction (SPE) and high resolution mass spectrometry (GC-HRMS EI SIM). Concentrations reported are given in pg/ml plasma and in ng/g plasma lipid (ppb). Lipid contents were determined enzymatically. For the sum of the 33 PCBs the average level, on lipid basis, was 340 ppb (range 1979-61 ppb), for PCB 153 the average was 81 ppb (range 460-13 ppb), HCB 41 ppb (range 143-12 ppb), oxychlordane 2.3 ppb (range 270.06), p,p-DDE 131 ppb (range 1114-7.3 ppb) and PBDE #47 had an average level of 2.5 ppb (range 25-0.4 ppb). A reference sample confirms the method performance to have a SD of 13% for the total PCB.